This review explores the anti-diabetic potential of Costus pictus stem, focusing on its pharmacological attributes and clinical implications. Costus pictus, widely known for its traditional medicinal uses, has garnered attention for its impact on diabetes management. The examination of its phytochemical composition reveals compounds with anti-diabetic properties, influencing glucose homeostasis, insulin sensitivity, and inflammation. Mechanisms of action involve modulation of insulin signaling pathways, enzymatic activity in glucose metabolism, and antioxidant effects on pancreatic beta cells. Clinical studies demonstrate its efficacy in stabilizing blood glucose levels. Additionally, the review delves into comparative efficacy with other anti-diabetic agents, safety considerations, and future research opportunities. Costus pictus stem emerges as a promising candidate in the realm of anti-diabetic therapeutics, emphasizing the need for further exploration and clinical validation